diagnostic value of fecal calprotectin in patient with ulcerative colitis
نویسندگان
چکیده
abstract background ulcerative colitis (uc) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. it is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. the aim of the current study is to evaluate the value of fecal calprotectin (fc) as a marker of disease activity in patients with uc. methods seventy three eligible subjects underwent ileocolonoscopy and multiple biopsies were obtained from different parts of the colon and terminal ileum. all patients underwent blood and stool sampling as well as an interview to assess the disease severity utilizing ulcerative colitis activity index (ucai), subjectively. the diagnostic value of the fc in comparison with mayo disease activity index as the gold standard technique, was then evaluated. results mean fc level increased linearly according to mayo disease activity index (r=0.44, p <0.001) and was significantly different between levels of mayo disease activity index ( p =0.003). in multivariate analysis, mayo disease activity index, positive crp and esr were associated with fc level. fc level > 21.4 ng/ml was able to discriminate between active and inactive phases of uc according to mayo disease activity index>2 with 72.3% sensitivity and 73.1% specificity. the combination of â fc > 21.4 ng/ml and ucai score of 7 had a 46.8% sensitivity and 88% specificity to diagnose mayo disease activity index >2. â furthermore, fc level <21.4 ng/ml in combination with ucai score of <3 showed a highly considerable specificity of 98% to discriminate the remission phase of uc (mayo disease activity index <2), although with a low sensitivity(31%). conclusion fc appears to be a non-invasive biomarker with moderate accuracy to discriminate the active phase of inflammatory bowel disease (ibd). the value of fc especially in combination with ucai is highly considerable to rule out the mayo disease activity index >2.
منابع مشابه
Diagnostic Value of Fecal Calprotectin in Patient with Ulcerative Colitis
BACKGROUND Ulcerative colitis (UC) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. Calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. It is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. The aim of the current study is to evaluate...
متن کاملThe value of fecal calprotectin as a marker of intestinal inflammation in patients with ulcerative colitis.
BACKGROUND/AIMS To assess intestinal inflammation, simple, inexpensive and objective tools are desirable in inflammatory bowel disease. This study aimed to evaluate fecal calprotectin as a marker of active disease in ulcerative colitis. MATERIALS AND METHODS Sixty patients with a diagnosis of ulcerative colitis and 20 controls were recruited into the study. The disease activity of ulcerative ...
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متن کاملFecal Immunochemical Test and Fecal Calprotectin Results Show Different Profiles in Disease Monitoring for Ulcerative Colitis
Background/Aims Both fecal immunochemical test (FIT) and fecal calprotectin (Fcal) results are useful biomarkers for ulcerative colitis (UC). However, the situations in which each marker should be used are largely unknown. Methods A total of 110 colonoscopy intervals of UC patients were assessed, and correlations between changes in colonoscopic findings and changes in the two aforementioned f...
متن کاملFecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis.
BACKGROUND The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients. METHODS UC patients scheduled to undergo an ileocolonoscopy were enrolled and fecal samples for FC measurement were collected prior to the procedure. ...
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عنوان ژورنال:
middle east journal of digestive diseasesجلد ۵، شماره ۲، صفحات ۷۶-۰
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